Investigating a new treatment for asthma in adults with obesity
Glucagon-Like Peptide-1 Receptor Agonist Treatment in Adult, Obesity-Related, Symptomatic Asthma
['FUNDING_U01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11083029
This study is looking at how a medication called GLP-1RA might help adults with asthma related to obesity by improving their breathing and reducing inflammation, and if you join, you'll take either the medication or a placebo for 12 weeks to see how it works for you.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11083029 on ClinicalTrials.gov |
What this research studies
This research focuses on the effects of glucagon-like peptide-1 receptor agonists (GLP-1RA) on asthma control and inflammation in adults suffering from obesity-related asthma. The study aims to determine how this treatment can improve asthma symptoms and reduce inflammation in the airways and adipose tissue. Participants will be involved in a 12-week trial where they will receive either the medication or a placebo, allowing researchers to assess the treatment's efficacy and tolerability. The ultimate goal is to gather data that could lead to larger clinical trials and better treatment options for this specific patient group.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with obesity-related asthma who do not have type 2 diabetes.
Not a fit: Patients who do not have asthma or those with asthma not related to obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved asthma management and quality of life for adults with obesity-related asthma.
How similar studies have performed: Previous research has shown promise in using GLP-1RA for other conditions, but this specific application in obesity-related asthma is novel.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAHILL, KATHERINE N — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: CAHILL, KATHERINE N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus