Investigating a new treatment for aortic aneurysm
Role of Protein Phosphatase 2A in Aortic Aneurysm
This study is looking at how a specific protein affects the growth of aortic aneurysms, which are dangerous bulges in the aorta, and aims to create new medications that could help treat this condition and possibly reduce the need for surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10317079 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Protein Phosphatase 2A in the development and progression of aortic aneurysms, a serious condition characterized by the abnormal widening of the aorta. The study aims to develop small molecule activators of Protein Phosphatase 2A (SMAPs) as potential therapeutic agents to improve treatment options for patients with this condition. By exploring the molecular mechanisms involved in aortic aneurysm formation, the research seeks to identify new strategies for managing and treating this life-threatening disease. Patients may benefit from novel pharmacologic therapies that could reduce the need for urgent surgical interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with aortic aneurysms or those at high risk for developing this condition.
Not a fit: Patients with aortic aneurysms who are not eligible for pharmacologic interventions or those who have already undergone surgical treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new medications that improve treatment outcomes for patients with aortic aneurysms.
How similar studies have performed: While the approach of targeting Protein Phosphatase 2A is relatively novel, similar studies in other cardiovascular conditions have shown promising results.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lin, Zhiyong — Emory University
- Study coordinator: Lin, Zhiyong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.