Investigating a new treatment for alcohol use disorder using alpha-1 blockade
A focus on alpha-1 blockade as a novel pharmacological treatment for alcohol use disorder
This study is testing a new way to help people with alcohol use disorder by using a medication called doxazosin to see if it can reduce cravings and drinking, especially when stress is involved, and it’s open to those looking for support in their recovery journey.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10693159 on NIH RePORTER |
What this research studies
This research focuses on a novel approach to treating alcohol use disorder (AUD) by targeting the stress response system. It involves a 12-week clinical trial where participants will receive either doxazosin, a medication that blocks norepinephrine, or a placebo. The study aims to assess changes in alcohol consumption and cravings, as well as the effects of stress on these behaviors. Participants will be monitored throughout the treatment period and in a controlled laboratory setting to evaluate their responses to alcohol-related cues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals seeking treatment for alcohol use disorder.
Not a fit: Patients who are not seeking treatment for alcohol use disorder or those with contraindications to doxazosin may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new pharmacological treatment option for individuals struggling with alcohol use disorder.
How similar studies have performed: Previous pilot trials have shown promising results in targeting the stress response for treating alcohol use disorder, suggesting potential for success in this approach.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Haass-Koffler, Carolina Luisa — Brown University
- Study coordinator: Haass-Koffler, Carolina Luisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.