Investigating a new treatment for aggressive nerve sheath tumors with PRC2 loss
Phase II Study of ASTX727 in Patients with PRC2 loss Malignant Peripheral Nerve Sheath Tumor (MPNST)
This study is looking at a new treatment for people with malignant peripheral nerve sheath tumors (MPNST) to see if targeting a specific protein can make existing therapies work better and improve outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10893373 on NIH RePORTER |
What this research studies
This research focuses on malignant peripheral nerve sheath tumors (MPNST), which are aggressive cancers with poor outcomes. The study aims to explore the effects of a new treatment targeting the loss of the PRC2 protein, which is common in these tumors. By using a specialized RNA interference library, researchers have identified a potential therapeutic target, DNMT1, that may enhance the effectiveness of existing treatments. Patients will be monitored for responses to this targeted therapy, which could lead to improved outcomes for those with MPNST.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with malignant peripheral nerve sheath tumors that exhibit loss of PRC2.
Not a fit: Patients with MPNST who do not have PRC2 loss or those with other types of tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new effective treatment option for patients suffering from MPNST.
How similar studies have performed: While research on MPNST is ongoing, this specific approach targeting PRC2 loss is novel and has not been extensively tested in clinical settings.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Chi, Ping — Sloan-Kettering Inst Can Research
- Study coordinator: Chi, Ping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.