Investigating a new treatment for age-related muscle loss and frailty
Catestatin and its mimetic pharmacophore TKO-10-18 as potential therapies for age-associated muscle loss and the consequent frailty
This study is looking at new treatments for sarcopenia, which is when older adults lose muscle strength and mass, and it will test a special peptide to see if it can help improve muscle health and function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-10940584 on NIH RePORTER |
What this research studies
This research focuses on developing potential therapies for sarcopenia, the age-related loss of muscle mass and function, which significantly impacts the health and quality of life of older adults. The study will explore the effects of a peptide called catestatin and its mimetic, TKO-10-18, on reversing the muscle deterioration associated with aging. By examining how these compounds influence inflammation, muscle strength, and neuromuscular junction function, the research aims to provide a new avenue for treating this condition. Participants may be involved in trials assessing the safety and effectiveness of these therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 65 and older who are experiencing age-related muscle loss.
Not a fit: Patients under 21 years old or those without signs of muscle loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for sarcopenia, improving muscle health and quality of life for older adults.
How similar studies have performed: While the approach is innovative, similar studies targeting neuromuscular function and inflammation in aging have shown promise, indicating potential for success.
Where this research is happening
San Diego, United States
- VA San Diego Healthcare System — San Diego, United States (Active)
Researchers
- Principal investigator: Mahata, Sushil K — VA San Diego Healthcare System
- Study coordinator: Mahata, Sushil K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.