Investigating a new treatment for a rare eye disease
Official title: Gyrate Atrophy Ocular and Systemic Study (GYROS)
Funded at Jaeb Center for Health Research, INC. · NIH-10701010 · Data updated 2026-11-12
This study is looking at a rare eye condition called gyrate atrophy and is testing a new gene therapy that could help improve or keep your vision while making it easier to manage your diet, and it’s for people affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jaeb Center for Health Research, INC. NIH-funded |
| Lab location | 1 site (Tampa, UNITED STATES) |
| Project start | September 15, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $400,000 |
| NIH project number | 5R01FD007628-02 |
| Project ID | NIH-10701010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with gyrate atrophy due to OAT gene mutations.
✕Less likely to help
Patients with other forms of retinal degeneration unrelated to gyrate atrophy may not benefit from this research.
What this research studies
This research focuses on gyrate atrophy, a rare inherited condition that leads to severe vision loss due to mutations in the OAT gene. The team is developing a gene augmentation therapy that aims to improve or preserve vision while reducing reliance on a difficult dietary treatment. Over four years, they will study the natural progression of the disease, measuring metabolic levels and retinal degeneration, and gathering patient-reported outcomes. This comprehensive approach will help identify factors that influence disease progression and treatment response.
Why it matters
Potential benefit: If successful, this research could lead to a more effective treatment for patients with gyrate atrophy, potentially improving their vision and quality of life.
How similar studies have gone: While gene augmentation therapies are being explored in various conditions, this specific approach for gyrate atrophy is novel and has not been extensively tested.
Where this research is happening
-
Jaeb Center for Health Research, INC.
Tampa, United States Active
Researchers
- Principal investigator: Ayala, Allison Renee — Jaeb Center for Health Research, INC.
- Study coordinator: Ayala, Allison Renee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.