Investigating a new therapy to improve the maturation of arteriovenous fistulas in older adults
Official title: Translational study of RAGE-SIRT1 therapy for arteriovenous fistula maturation
Funded at VA Salt Lake City Healthcare System · NIH-10921808 · Data updated 2026-11-12
This study is looking at how specific proteins in blood vessel cells can help improve the growth of arteriovenous fistulas (AVFs) for people on hemodialysis, and it’s testing different small molecules to see if they can make these fistulas work better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006269-01A2 |
| Project ID | NIH-10921808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those over the age of 65, who are undergoing procedures to create arteriovenous fistulas for hemodialysis.
✕Less likely to help
Patients who are younger than 65 or those who do not require hemodialysis may not benefit from this research.
What this research studies
This research focuses on understanding how certain receptors and proteins in blood vessel cells affect the maturation of arteriovenous fistulas (AVFs), which are crucial for patients requiring hemodialysis. The study aims to explore the impact of small-molecule inhibitors and activators on these receptors to enhance AVF maturation. By examining the relationship between blood flow disturbances and cellular damage, the research seeks to identify potential therapeutic strategies to improve outcomes for patients with AVF maturation failure.
Why it matters
Potential benefit: If successful, this research could lead to improved techniques for ensuring that arteriovenous fistulas mature properly, enhancing the quality of life for patients requiring dialysis.
How similar studies have gone: While the specific approach of targeting RAGE and SIRT1 in AVF maturation is novel, similar research has shown promise in understanding vascular biology and improving outcomes in related conditions.
Where this research is happening
-
VA Salt Lake City Healthcare System
Salt Lake City, United States Active
Researchers
- Principal investigator: Shiu, Yan-Ting E. — VA Salt Lake City Healthcare System
- Study coordinator: Shiu, Yan-Ting E.
Related research
Other NIH-funded projects on the same topics.
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Cardiovascular changes after AV fistula creation and how autophagy affects it
A VA-led project looks at how blood vessel remodeling after AV fistula surgery may be helped by understanding and targeting autophagy.
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Nanoparticle delivery to prevent AV fistula narrowing
A new nanoparticle-based approach aims to prevent AV fistula narrowing in people with kidney failure who rely on dialysis.
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Molecular control of arterial-to-vein remodeling in fistula maturation
This study explores how vein cells change to help arteriovenous fistulas mature, with the aim of improving outcomes for people needing hemodialysis.
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How the protein calprotectin affects healing of dialysis fistulas
Looking at whether a protein called calprotectin causes narrowing that keeps new dialysis fistulas from becoming usable for people with kidney failure.
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Improving AV fistula longevity by guiding vein remodeling
A research project is exploring how to help veins adapt better when used for hemodialysis access so patients have fewer costly procedures.
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Bioabsorbable wrap to improve AV fistula outcomes
A new bioabsorbable wrap is being studied to help AV fistula surgery heal better and stay open longer for people needing hemodialysis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.