Investigating a new therapy to improve the maturation of arteriovenous fistulas in older adults
Translational study of RAGE-SIRT1 therapy for arteriovenous fistula maturation
This study is looking at how specific proteins in blood vessel cells can help improve the growth of arteriovenous fistulas (AVFs) for people on hemodialysis, and it’s testing different small molecules to see if they can make these fistulas work better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10921808 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain receptors and proteins in blood vessel cells affect the maturation of arteriovenous fistulas (AVFs), which are crucial for patients requiring hemodialysis. The study aims to explore the impact of small-molecule inhibitors and activators on these receptors to enhance AVF maturation. By examining the relationship between blood flow disturbances and cellular damage, the research seeks to identify potential therapeutic strategies to improve outcomes for patients with AVF maturation failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over the age of 65, who are undergoing procedures to create arteriovenous fistulas for hemodialysis.
Not a fit: Patients who are younger than 65 or those who do not require hemodialysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved techniques for ensuring that arteriovenous fistulas mature properly, enhancing the quality of life for patients requiring dialysis.
How similar studies have performed: While the specific approach of targeting RAGE and SIRT1 in AVF maturation is novel, similar research has shown promise in understanding vascular biology and improving outcomes in related conditions.
Where this research is happening
Salt Lake City, United States
- VA Salt Lake City Healthcare System — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Shiu, Yan-Ting E. — VA Salt Lake City Healthcare System
- Study coordinator: Shiu, Yan-Ting E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.