Investigating a new target to prevent atherosclerosis
Official title: RECK as a Therapeutic Target for Atherosclerosis
Funded at Tulane University of Louisiana · NIH-11050406 · Data updated 2026-11-12
This study is looking at how a protein called RECK might help stop heart disease by keeping blood vessels healthy and reducing inflammation, which could lead to new treatments for people at risk of atherosclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $646,106 |
| NIH project number | 1R01HL170056-01A1 |
| Project ID | NIH-11050406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis or those with early signs of cardiovascular disease.
✕Less likely to help
Patients with advanced cardiovascular disease or those who do not have atherosclerosis may not benefit from this research.
What this research studies
This research aims to explore the role of a protein called RECK in preventing the development and progression of atherosclerosis, a major cause of heart disease. By studying how RECK affects inflammation and cell behavior in blood vessels, the researchers hope to identify new therapeutic strategies. The approach involves examining the effects of RECK on specific cell types involved in atherosclerosis, such as vascular smooth muscle cells and macrophages. If successful, this research could lead to innovative treatments that reduce the risk of cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options to prevent or slow down the progression of atherosclerosis and related cardiovascular diseases.
How similar studies have gone: Other research has shown promising results in targeting similar pathways for atherosclerosis treatment, suggesting potential for success in this approach.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Higashi, Yusuke — Tulane University of Louisiana
- Study coordinator: Higashi, Yusuke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.