Investigating a new target to improve cognitive recovery after stroke
Official title: A New Molecular Target to Enhance Poststroke Cognitive Recovery
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11075349 · Data updated 2026-11-12
This study is looking at how a protein called DKK3 might help stroke survivors improve their thinking and memory skills after a stroke, with the hope of finding new ways to support their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $698,892 |
| NIH project number | 5R01NS125262-03 |
| Project ID | NIH-11075349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a stroke and are experiencing cognitive difficulties.
✕Less likely to help
Patients who have not had a stroke or those with advanced dementia may not benefit from this research.
What this research studies
This research focuses on understanding and improving cognitive recovery in stroke survivors, particularly those experiencing post-stroke cognitive impairment (PSCI). The team will explore the role of a specific protein, DKK3, in the brain's response to stroke and how it may help mitigate cognitive deficits. Using an experimental model of stroke, they will assess the timing and effectiveness of treatments aimed at enhancing cognitive function following a stroke. The goal is to identify new therapeutic strategies that could lead to better outcomes for patients recovering from strokes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve cognitive recovery for stroke survivors.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for cognitive recovery after stroke, suggesting potential for success in this approach.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Li, Guohong — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Li, Guohong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.