Investigating a new target for treating pulmonary arterial hypertension
NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH
This study is looking at how a specific molecule in the body might play a role in the development of pulmonary arterial hypertension (PAH), a serious lung condition, to help find ways to better understand and predict the disease for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11017036 on NIH RePORTER |
What this research studies
This research focuses on pulmonary arterial hypertension (PAH), a serious condition with no current cure. It explores how NAD-dependent signaling, particularly through a molecule called NAMPT, affects the development and progression of PAH. The study aims to understand how this signaling pathway influences cellular and molecular changes in the lungs, which contribute to the disease. Researchers will also work on identifying biomarkers that could help predict susceptibility to PAH and its prognosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension.
Not a fit: Patients with other forms of pulmonary hypertension or those without a diagnosis of pulmonary arterial hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating pulmonary arterial hypertension.
How similar studies have performed: Other research has shown promising results in targeting similar signaling pathways for various diseases, suggesting potential for success in this area as well.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Machado, Roberto F. — Indiana University Indianapolis
- Study coordinator: Machado, Roberto F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.