Investigating a new target for treating neuropathic pain
Genetic and Pharmacological Validation of CRMP2 Phosphorylation as a Novel therapeutic Target for Neuropathic Pain
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-11106096
This study is looking at a protein called CRMP2 to see how it affects pain after nerve injuries, with the hope of finding new ways to help people manage chronic pain better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11106096 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a specific protein, CRMP2, is involved in the development of neuropathic pain after nerve injury. By examining the phosphorylation of CRMP2, the researchers aim to identify new mechanisms that could lead to targeted medications for better pain management. The study will explore how changes in CRMP2 affect pain sensitivity and whether manipulating its phosphorylation can provide relief from chronic pain. Patients may benefit from new treatments developed from these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from neuropathic pain, particularly those who have not responded well to existing treatments.
Not a fit: Patients with pain conditions unrelated to neuropathic mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that more effectively manage neuropathic pain.
How similar studies have performed: Previous studies have shown promise in targeting similar pathways for pain management, suggesting potential for success in this novel approach.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHANNA, RAJESH — UNIVERSITY OF FLORIDA
- Study coordinator: KHANNA, RAJESH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.