Investigating a new target for treating lupus
HIPK1: a new immunomodulatory target for SLE
This study is looking at how a protein called HIPK1 affects the immune system in people with lupus, with the hope of finding new ways to help manage the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10893550 on NIH RePORTER |
What this research studies
This research explores the role of the HIPK1 kinase in systemic lupus erythematosus (SLE), a complex autoimmune disease. By examining the 3D structure of the genome in immune cells, the study aims to understand how HIPK1 influences T cell differentiation and antibody responses. Researchers will employ genetic and pharmacologic methods in both human and mouse models to assess the impact of HIPK1 on SLE pathophysiology. The goal is to uncover new immunomodulatory strategies for managing lupus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus.
Not a fit: Patients with other autoimmune diseases not related to SLE may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve the management of systemic lupus erythematosus.
How similar studies have performed: While HIPK1 has been studied in cancer, its role in immunity and SLE is novel and has not been previously explored.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wells, Andrew D — Children's Hosp of Philadelphia
- Study coordinator: Wells, Andrew D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.