Investigating a new target for treating lung cancer
Official title: ER stress-driven IRE1a-XBP1 signaling in lung cancer
Funded at Weill Medical Coll of Cornell Univ · NIH-11017796 · Data updated 2026-11-12
This study is looking at how a specific process in cells might help non-small cell lung cancer grow, with the goal of finding new ways to treat the disease and improve outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $663,481 |
| NIH project number | 5R01CA271619-03 |
| Project ID | NIH-11017796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who may benefit from new treatment options.
✕Less likely to help
Patients with other types of lung cancer or those who are not diagnosed with cancer may not receive any benefit from this research.
What this research studies
This research focuses on the role of a specific cellular stress response pathway, known as IRE1α-XBP1 signaling, in the progression of non-small cell lung cancer (NSCLC). The study aims to understand how this pathway contributes to cancer development and how targeting it could lead to new therapeutic strategies. By examining the tumor microenvironment and the effects of ER stress on cancer cells, researchers hope to identify novel treatment options that could improve patient outcomes. The approach includes both laboratory experiments and analysis of cancer models to validate the findings.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for lung cancer patients, potentially improving survival rates.
How similar studies have gone: Previous research has shown promise in targeting similar cellular stress pathways in cancer, indicating potential for success in this novel approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Mittal, Vivek — Weill Medical Coll of Cornell Univ
- Study coordinator: Mittal, Vivek
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.