Investigating a new target for treating heart failure with preserved ejection fraction.
A Pathogenic Role for the Natriuretic Peptide Clearance Receptor in Heart Failure with Preserved Ejection Fraction.
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-10765668
This study is looking at how obesity and metabolic issues affect heart function in veterans with heart failure and aims to find new ways to help improve their health by exploring a specific target in the body.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10765668 on ClinicalTrials.gov |
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a condition affecting many US Veterans with no current treatments that reduce mortality. The study aims to understand how obesity and metabolic dysfunction impact the metabolism of the right ventricle, which is crucial for heart function. By exploring a novel therapeutic target, the natriuretic peptide clearance receptor, the research seeks to identify potential therapies that could improve outcomes for patients suffering from this condition. The principal investigator, Dr. Vineet Agrawal, will receive mentorship and resources to advance this important work.
Who could benefit from this research
Good fit: Ideal candidates for this research are Veterans diagnosed with heart failure with preserved ejection fraction, particularly those experiencing right ventricular failure.
Not a fit: Patients with heart failure types other than preserved ejection fraction or those without metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the health and survival of patients with heart failure with preserved ejection fraction.
How similar studies have performed: While the approach of targeting metabolic dysfunction in heart failure is being explored, this specific investigation into the natriuretic peptide clearance receptor is novel and has not been extensively tested.
Where this research is happening
NASHVILLE, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AGRAWAL, VINEET — VETERANS HEALTH ADMINISTRATION
- Study coordinator: AGRAWAL, VINEET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.