Investigating a new target for treating heart failure with preserved ejection fraction.
Official title: A Pathogenic Role for the Natriuretic Peptide Clearance Receptor in Heart Failure with Preserved Ejection Fraction.
Funded at Veterans Health Administration · NIH-10765668 · Data updated 2026-11-12
This study is looking at how obesity and metabolic issues affect heart function in veterans with heart failure and aims to find new ways to help improve their health by exploring a specific target in the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 1, 2023 |
| Project end | March 30, 2028 |
| Funding year | 2024 |
| NIH project number | 5IK2BX005828-02 |
| Project ID | NIH-10765668 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans diagnosed with heart failure with preserved ejection fraction, particularly those experiencing right ventricular failure.
✕Less likely to help
Patients with heart failure types other than preserved ejection fraction or those without metabolic dysfunction may not benefit from this research.
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a condition affecting many US Veterans with no current treatments that reduce mortality. The study aims to understand how obesity and metabolic dysfunction impact the metabolism of the right ventricle, which is crucial for heart function. By exploring a novel therapeutic target, the natriuretic peptide clearance receptor, the research seeks to identify potential therapies that could improve outcomes for patients suffering from this condition. The principal investigator, Dr. Vineet Agrawal, will receive mentorship and resources to advance this important work.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the health and survival of patients with heart failure with preserved ejection fraction.
How similar studies have gone: While the approach of targeting metabolic dysfunction in heart failure is being explored, this specific investigation into the natriuretic peptide clearance receptor is novel and has not been extensively tested.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Agrawal, Vineet — Veterans Health Administration
- Study coordinator: Agrawal, Vineet
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.