Investigating a new target for stroke treatment
Official title: Ifi27l2a as a therapeutic target for stroke
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11083116 · Data updated 2026-11-12
This study is looking at a protein called Ifi27l2a to see how it helps the brain respond to stroke, especially in older adults, with the hope that understanding it better could lead to new treatments that help people recover more effectively after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $500,372 |
| NIH project number | 5R01NS133324-03 |
| Project ID | NIH-11083116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 65 and above, who have experienced a stroke.
✕Less likely to help
Patients who are younger than 65 or have not suffered a stroke may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein, Ifi27l2a, in the brain's immune response to stroke, particularly in older adults. The study aims to explore how this protein affects inflammation and recovery after a stroke by analyzing brain cells from both mice and humans. By using advanced techniques like single-cell transcriptomic analysis, the researchers hope to identify how manipulating this protein could improve outcomes for stroke patients. The ultimate goal is to develop targeted therapies that enhance recovery and reduce damage caused by stroke.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and outcomes for stroke patients, especially those over 65.
How similar studies have gone: Previous research has shown promise in targeting immune responses in stroke recovery, suggesting that this approach could be beneficial.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Kim, Gab Seok — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Kim, Gab Seok
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.