Investigating a new target for pain relief
Official title: FABP5: Novel Functions in Pain Modulation
Funded at State University New York Stony Brook · NIH-11043378 · Data updated 2026-11-12
This study is looking at how a protein called FABP5 affects pain and aims to create new pain relief options that don't involve addictive opioids, helping people with chronic pain feel better naturally.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $453,974 |
| NIH project number | 5R01NS137595-02 |
| Project ID | NIH-11043378 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing chronic pain who are seeking alternatives to opioid medications.
✕Less likely to help
Patients who do not experience chronic pain or have conditions unrelated to pain management may not benefit from this research.
What this research studies
This research focuses on understanding the role of fatty acid binding protein 5 (FABP5) in pain modulation. The team aims to develop non-opioid analgesics that can effectively manage chronic pain without the risk of addiction associated with current opioid treatments. By inhibiting FABP5, they hope to enhance the levels of natural pain-relieving compounds in the body and reduce inflammation that contributes to pain. The research includes preclinical testing of new FABP5 inhibitors, with plans for clinical trials in the near future.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective pain management options for patients suffering from chronic pain.
How similar studies have gone: Other research has shown promising results with similar approaches targeting lipid transport mechanisms for pain relief, indicating potential for success in this area.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Kaczocha, Martin — State University New York Stony Brook
- Study coordinator: Kaczocha, Martin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.