Investigating a new target for diagnosing and treating prostate cancer
Official title: PSMA’s enzymatic activity as new target for Prostate Cancer diagnosis and therapy
Funded at Sloan-Kettering Inst Can Research · NIH-10877944 · Data updated 2026-11-12
This study is looking at how a specific protein called PSMA affects prostate cancer, especially when it becomes harder to treat after hormone therapy, and aims to create new personalized treatments and better ways to diagnose and track the disease for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $697,822 |
| NIH project number | 5R01CA257811-04 |
| Project ID | NIH-10877944 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with prostate cancer, particularly those who have progressed to castration-resistant prostate cancer.
✕Less likely to help
Patients with early-stage prostate cancer who have not yet undergone hormone therapy may not benefit from this research.
What this research studies
This research focuses on prostate cancer, particularly the challenges faced when patients progress to castration-resistant prostate cancer (CRPC) after initial hormone therapy. The team aims to explore the role of prostate-specific membrane antigen (PSMA) in cancer growth, utilizing its enzymatic activity to develop a novel personalized therapy. By understanding how PSMA interacts with key signaling pathways, the researchers hope to create new treatment strategies that could improve patient outcomes. Additionally, they are developing a companion imaging assay to help diagnose and monitor prostate cancer more effectively.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with advanced prostate cancer.
How similar studies have gone: Previous research has shown promise in targeting similar pathways in cancer treatment, suggesting potential for success in this novel approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Grimm, Jan — Sloan-Kettering Inst Can Research
- Study coordinator: Grimm, Jan
Related research
Other NIH-funded projects on the same topics.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Targeting PSMA for Prostate Cancer Diagnosis and Treatment
This project explores a new way to find and treat advanced prostate cancer by focusing on a specific protein called PSMA.
-
Using advanced digital imaging and AI to improve prostate cancer diagnosis
This study is working on using advanced computer technology to help doctors better understand prostate cancer by analyzing tissue samples, making it easier to spot tumors and explain the results clearly.
-
Improving prostate cancer diagnosis using advanced ultrasound techniques
This study is testing a new type of ultrasound to help doctors find serious prostate cancer more accurately and affordably, so patients can get the right treatment without unnecessary procedures for less aggressive cases.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.