Investigating a new system that helps cells manage damaged proteins and its link to cancer development
A novel protein quality control system and its role in tumorigenesis
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10893924
This study is looking at how certain proteins in our cells help get rid of damaged ones, especially in cancer cells, to see if this process might be linked to how cancer grows, which could help find new ways to treat the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10893924 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding a novel protein quality control system in mammalian cells and its potential role in the development of cancer. The researchers will explore how cancer cells may have an enhanced ability to eliminate misfolded proteins, which could contribute to their uncontrolled growth. By studying specific proteins known as TRIMs, which help mark damaged proteins for degradation, the team aims to uncover how these processes are altered in cancerous cells. This could lead to new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer who may benefit from advancements in understanding tumor biology.
Not a fit: Patients with non-cancerous conditions or those who are not currently undergoing treatment for cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer treatment by targeting the mechanisms that allow cancer cells to thrive despite cellular stress.
How similar studies have performed: Other research has shown promising results in targeting protein quality control mechanisms in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, XIAOLU — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: YANG, XIAOLU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.