Investigating a new site on the HIV virus to improve vaccine development
Immunogenicity of the newly identified V3 crown vulnerable site
['FUNDING_R21'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10659226
This study is looking at a new part of the HIV virus that could help boost the immune response, with the goal of finding better ways to create an effective vaccine for people living with HIV.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10659226 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying and characterizing a newly discovered vulnerable site on the HIV-1 virus that could enhance the immune response to the virus. By mapping the epitope of a broadly neutralizing antibody (bnAb) known as M4008_N1, the researchers aim to understand how to induce effective antibody responses against HIV. The study employs advanced techniques like cryo-electron microscopy to analyze the interaction between the antibody and the virus, which may lead to improved vaccine strategies. Patients may benefit from this research as it could contribute to the development of a more effective HIV vaccine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of HIV infection or those living with HIV who are interested in advancements in vaccine development.
Not a fit: Patients who are already on effective antiretroviral therapy and have a well-controlled HIV infection may not directly benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective vaccine against HIV, potentially reducing the incidence of HIV infections.
How similar studies have performed: Previous research has shown promise in targeting similar vulnerable sites on the HIV virus, indicating that this approach may yield successful outcomes.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KONG, XIANGPENG — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: KONG, XIANGPENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.