Investigating a new signaling pathway in Barrett's esophagus and its progression to cancer
Official title: EPHB2-Dependent Signaling: A New Molecular Paradigm in Barrett's Neoplasia
Funded at Case Western Reserve University · NIH-10932163 · Data updated 2026-11-12
This study is looking at how Barrett's esophagus can lead to a serious type of cancer, and it aims to find out more about the biological processes involved so that we can create better ways to detect and prevent the disease for patients like you.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $387,708 |
| NIH project number | 5P01CA269019-02 |
| Project ID | NIH-10932163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Barrett's esophagus who are at risk of developing esophageal adenocarcinoma.
✕Less likely to help
Patients without Barrett's esophagus or those with advanced esophageal cancer may not benefit from this research.
What this research studies
This research focuses on understanding Barrett's esophagus (BE), a condition that increases the risk of developing esophageal adenocarcinoma (EAC), a serious type of cancer. The team aims to identify the underlying mechanisms that lead to BE and its progression to cancer by studying the EphB2 receptor signaling pathway. They will analyze patient biopsies and use advanced techniques like RNA sequencing to uncover how this pathway contributes to the disease. The ultimate goal is to develop biomarkers and preventive strategies that can be used in clinical settings to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and preventive treatments for patients at risk of esophageal cancer.
How similar studies have gone: Previous research has shown promising results in understanding signaling pathways in cancer, making this approach both innovative and potentially impactful.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Blum, Andrew Edward — Case Western Reserve University
- Study coordinator: Blum, Andrew Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.