Investigating a new RNA molecule that may protect the heart after a heart attack
Cardioprotective mechanisms of novel noncoding RNA in myocardial infarction
This study is looking at a special molecule called TY4 that comes from tiny particles in the body and might help protect the heart after a heart attack, and it’s testing how well it works with a protein from breast milk to see if it can be taken as a pill to help people recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11060981 on NIH RePORTER |
What this research studies
This research focuses on a novel noncoding RNA called TY4, which is derived from exosomes and has shown potential in protecting the heart during and after a myocardial infarction. The study aims to understand how TY4 influences inflammatory and fibrotic pathways, potentially leading to improved heart function. By using animal models, researchers will explore the effectiveness of TY4 when combined with a protein found in breast milk, assessing its ability to be administered orally. The goal is to uncover new therapeutic strategies for heart disease that could be beneficial for patients recovering from heart attacks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have suffered from a myocardial infarction or are at risk for heart disease.
Not a fit: Patients with non-cardiac conditions or those who have not experienced heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and heart health for patients who have experienced a heart attack.
How similar studies have performed: While the approach of using noncoding RNA for cardioprotection is relatively novel, preliminary data suggest promising results in similar research areas.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Marban, Eduardo — Cedars-Sinai Medical Center
- Study coordinator: Marban, Eduardo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.