Investigating a new RNA molecule that may protect the heart after a heart attack
Official title: Cardioprotective mechanisms of novel noncoding RNA in myocardial infarction
Funded at Cedars-Sinai Medical Center · NIH-11060981 · Data updated 2026-11-12
This study is looking at a special molecule called TY4 that comes from tiny particles in the body and might help protect the heart after a heart attack, and it’s testing how well it works with a protein from breast milk to see if it can be taken as a pill to help people recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $620,352 |
| NIH project number | 5R01HL164588-03 |
| Project ID | NIH-11060981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have suffered from a myocardial infarction or are at risk for heart disease.
✕Less likely to help
Patients with non-cardiac conditions or those who have not experienced heart-related issues may not benefit from this research.
What this research studies
This research focuses on a novel noncoding RNA called TY4, which is derived from exosomes and has shown potential in protecting the heart during and after a myocardial infarction. The study aims to understand how TY4 influences inflammatory and fibrotic pathways, potentially leading to improved heart function. By using animal models, researchers will explore the effectiveness of TY4 when combined with a protein found in breast milk, assessing its ability to be administered orally. The goal is to uncover new therapeutic strategies for heart disease that could be beneficial for patients recovering from heart attacks.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and heart health for patients who have experienced a heart attack.
How similar studies have gone: While the approach of using noncoding RNA for cardioprotection is relatively novel, preliminary data suggest promising results in similar research areas.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Marban, Eduardo — Cedars-Sinai Medical Center
- Study coordinator: Marban, Eduardo
Related research
Other NIH-funded projects on the same topics.
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Anti-inflammatory signaling of a key protein in heart attack recovery
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This grant studies a specific cell-death pathway (RIPK3) to protect the heart after a heart attack, with the goal of reducing damage and improving recovery.
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A new treatment approach uses engineered secretions from immune cells delivered early after a heart attack to reduce inflammation, promote blood vessel growth, and limit scarring to protect heart function.
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This project follows adults across the U.S. to see how lifelong social and neighborhood factors shape heart attacks, heart failure, and recovery, with attention to Black adults and regions with high disease rates.
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Real-time multi-lead ECG from wearables to help detect heart attacks early
A new AI-based approach uses everyday wearable sensors to turn simple PPG signals into multi-lead ECG data to monitor for heart attacks in real time, even outside the clinic.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.