Investigating a new rat model for Alzheimer's disease
Presenilin Knock-in Rat Model of Neurodegeneration
This study is looking at how certain genetic changes linked to Alzheimer's disease affect brain function in specially bred rats, with the hope that what we learn can help develop new treatments for people with the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11018521 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms of neurodegeneration in Alzheimer's disease (AD) using a novel rat model that carries specific mutations associated with familial Alzheimer's. The study aims to characterize how these mutations affect brain function and contribute to the progression of the disease. By utilizing rats, which are more suitable for surgical interventions and behavioral testing, researchers hope to gain insights that could lead to potential therapies. The project will explore the effects of the Presenilin1 mutation on neurodegeneration, providing a platform for future studies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with familial Alzheimer's disease or those at high risk due to genetic factors.
Not a fit: Patients with sporadic Alzheimer's disease or those without a genetic predisposition to familial forms of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease and pave the way for the development of disease-modifying therapies.
How similar studies have performed: Previous research has shown success in using animal models to study Alzheimer's disease, indicating that this approach has the potential for meaningful insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Tambini, Marc D — Rutgers Biomedical and Health Sciences
- Study coordinator: Tambini, Marc D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.