Investigating a new protein's role in heart function
Official title: Examining the Function of a Novel Protein in the Cardiac Junctional Membrane Complex
Funded at University of Iowa · NIH-11031297 · Data updated 2026-11-12
This study is looking at a special protein called Junctophilin 1 to see how it helps the heart work properly, especially in people with heart failure, by using mice to learn more about its role in heart health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $34,137 |
| NIH project number | 5F31HL170655-02 |
| Project ID | NIH-11031297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of heart disease or those experiencing early signs of heart failure.
✕Less likely to help
Patients with non-cardiac related health issues or those who do not have any heart-related conditions may not benefit from this research.
What this research studies
This research focuses on understanding how a novel protein, Junctophilin 1 (JP1), functions within the cardiac junctional membrane complexes, which are crucial for heart muscle contraction and calcium signaling. By studying mouse models, researchers aim to uncover the effects of JP1 on heart health, particularly in the context of heart failure. The approach involves examining the expression of JP1 in cardiac tissues and its interactions with other proteins that regulate heart function. This could lead to insights into how disruptions in these proteins contribute to heart disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating heart failure by targeting the mechanisms involving JP1.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar proteins in cardiac function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Ciampa, Grace — University of Iowa
- Study coordinator: Ciampa, Grace
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.