Investigating a new protein that regulates heart energy function
Perm1 is a Novel Regulator of Cardiac Energetics and Function
This study is looking at a protein called Perm1 to see how it affects heart cell energy and could help improve heart function for people with heart diseases like heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-10739812 on NIH RePORTER |
What this research studies
This research focuses on a protein called Perm1, which plays a crucial role in how heart cells produce and manage energy. By studying how Perm1 is affected in heart diseases, the researchers aim to uncover its potential to improve heart function and combat conditions like heart failure. The approach involves examining gene expression and mitochondrial function in heart cells, particularly under stress conditions. This could lead to new insights into treatments for patients with cardiac disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing heart-related issues or conditions such as heart failure.
Not a fit: Patients with non-cardiac conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance heart energy production and improve outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function in muscle, suggesting potential for success in cardiac applications.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Warren, Junko Shibayama — Virginia Polytechnic Inst and St Univ
- Study coordinator: Warren, Junko Shibayama
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.