Investigating a new protein linked to immune cell function
In vivo functional characterization of a novel protein encoded by a lncRNA
This study is looking at how a certain type of RNA affects immune cells called macrophages, which help protect us from infections, to see if it could lead to new treatments for serious conditions like septic shock.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11107035 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific long non-coding RNA (lncRNA) influences the function of immune cells, particularly macrophages, which play a crucial role in the body's defense against infections. By studying this lncRNA, researchers aim to uncover its potential as a therapeutic target for conditions like septic shock, where immune response is severely dysregulated. The approach involves characterizing the lncRNA's expression and its effects on immune cell behavior in both healthy and diseased states. Patients may benefit from insights gained that could lead to new treatments for immune-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve dysregulated immune responses, such as septic shock or other acute inflammatory diseases.
Not a fit: Patients with stable chronic conditions that do not involve acute immune dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve immune response and reduce tissue damage in patients with severe infections.
How similar studies have performed: Other research has shown promise in targeting non-coding RNAs for therapeutic purposes, indicating potential success for this novel approach.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Krementsov, Dimitry N — University of Vermont & St Agric College
- Study coordinator: Krementsov, Dimitry N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.