Investigating a new protein linked to immune cell function
Official title: In vivo functional characterization of a novel protein encoded by a lncRNA
Funded at University of Vermont & St Agric College · NIH-11107035 · Data updated 2026-11-12
This study is looking at how a certain type of RNA affects immune cells called macrophages, which help protect us from infections, to see if it could lead to new treatments for serious conditions like septic shock.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | February 24, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $74,346 |
| NIH project number | 1R03AI190196-01 |
| Project ID | NIH-11107035 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve dysregulated immune responses, such as septic shock or other acute inflammatory diseases.
✕Less likely to help
Patients with stable chronic conditions that do not involve acute immune dysregulation may not benefit from this research.
What this research studies
This research focuses on understanding how a specific long non-coding RNA (lncRNA) influences the function of immune cells, particularly macrophages, which play a crucial role in the body's defense against infections. By studying this lncRNA, researchers aim to uncover its potential as a therapeutic target for conditions like septic shock, where immune response is severely dysregulated. The approach involves characterizing the lncRNA's expression and its effects on immune cell behavior in both healthy and diseased states. Patients may benefit from insights gained that could lead to new treatments for immune-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve immune response and reduce tissue damage in patients with severe infections.
How similar studies have gone: Other research has shown promise in targeting non-coding RNAs for therapeutic purposes, indicating potential success for this novel approach.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Krementsov, Dimitry N — University of Vermont & St Agric College
- Study coordinator: Krementsov, Dimitry N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.