Investigating a new PET tracer to detect brain demyelination.
Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and Humans
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10740843
This study is testing a new imaging tool that helps doctors see and measure damage to the protective covering of nerves in the brain, which is important for understanding and treating conditions like multiple sclerosis and Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10740843 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel PET tracer, [18F]3F4AP, to detect brain demyelination, which is a key feature in conditions like multiple sclerosis and Alzheimer's disease. Currently, MRI is used to image demyelination, but it lacks the ability to quantify and differentiate it from other brain issues. The study aims to validate this new tracer in both nonhuman primates and humans, providing a more precise imaging technique that could enhance the understanding and treatment of demyelinating diseases. If successful, this approach could lead to improved monitoring and therapeutic strategies for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with multiple sclerosis, Alzheimer's disease, or those who have experienced traumatic brain injuries.
Not a fit: Patients with conditions unrelated to demyelination or those who do not have access to the research facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment options for patients with demyelinating diseases.
How similar studies have performed: Previous research has shown success with similar PET imaging approaches in animal models, but this specific tracer's application in humans is novel.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRUGAROLAS, PEDRO — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: BRUGAROLAS, PEDRO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease