Investigating a new pathway to reduce inflammation in Alzheimer's disease
Regulation of LC3-associated endocytosis and neuroinflammation
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-10991695
This study is looking at a new way that brain cells can help reduce inflammation and damage caused by Alzheimer's disease, with the hope of finding new treatments that could improve memory and protect brain cells for people living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10991695 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding a newly identified pathway called LC3-associated endocytosis (LANDO) that plays a crucial role in reducing neuroinflammation and neurodegeneration associated with Alzheimer's disease. By studying how LANDO functions in microglia, the brain's immune cells, the researchers aim to uncover mechanisms that could help mitigate the harmful effects of β-amyloid, a protein linked to Alzheimer's. The approach involves examining the recycling of receptors that recognize β-amyloid and how this process can suppress inflammatory signaling. The ultimate goal is to identify potential therapeutic targets that could improve memory and reduce neuronal loss in Alzheimer's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it due to age or genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting neuroinflammation in Alzheimer's disease, suggesting that this approach could yield significant advancements.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HECKMANN, BRADLEE L — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: HECKMANN, BRADLEE L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury