Investigating a new pathway for heart repair after injury
Official title: Hippo-YAP signaling in cardiac regenerative repair
Funded at Baylor College of Medicine · NIH-11058748 · Data updated 2026-11-12
This study is looking at how a specific signaling pathway in the heart can help it heal better after a heart attack, and they're working on new gene therapy methods to boost this healing process for people who have experienced heart injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 10, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $693,261 |
| NIH project number | 1R01HL173242-01A1 |
| Project ID | NIH-11058748 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced heart injury or heart failure.
✕Less likely to help
Patients with non-cardiac related health issues or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on the Hippo-YAP signaling pathway and its role in heart injury recovery. The team aims to develop gene therapy strategies that can enhance the heart's ability to heal after a heart attack. By studying how knocking down Hippo signaling can improve cardiac function, they hope to create innovative treatments that promote effective healing in heart tissue. The research will utilize advanced techniques, including single-cell genomics, to better understand the mechanisms involved in heart regeneration.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and outcomes for patients with heart failure.
How similar studies have gone: While the Hippo-YAP pathway is a relatively novel area of investigation, similar approaches in cardiac regeneration have shown promising results in preclinical studies.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Martin, James F — Baylor College of Medicine
- Study coordinator: Martin, James F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.