Investigating a new mouse model for understanding specific immune cells in tuberculosis
A new mouse model to study the function of CD1b-restricted germline encoded, mycolyl lipid-reactive (GEM) T cells
This study is looking at special immune cells that help fight tuberculosis, and it's testing a new mouse model to see how these cells work and if giving them to infected mice can help control the infection better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10867411 on NIH RePORTER |
What this research studies
This research focuses on a unique subset of immune cells known as CD1-restricted T cells, which play a crucial role in recognizing and responding to lipid antigens associated with Mycobacterium tuberculosis (Mtb) infection. By developing a new mouse model, the researchers aim to explore how these T cells function and their potential to limit Mtb growth. The study involves analyzing T cell responses and the effectiveness of adoptive transfer of specific T cells to combat Mtb infection. This approach could provide insights into enhancing immune responses against tuberculosis.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with a history of tuberculosis infection or those at high risk for developing the disease.
Not a fit: Patients who are not affected by tuberculosis or do not have a related immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating tuberculosis by harnessing the body's immune response.
How similar studies have performed: Previous research has shown promising results in understanding the role of CD1-restricted T cells in tuberculosis, indicating that this approach has potential for success.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Wang, Chyung-Ru — Northwestern University at Chicago
- Study coordinator: Wang, Chyung-Ru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.