Investigating a new mouse model for dry age-related macular degeneration
Modeling and mechanistic investigation of a novel dry AMD mouse model with CLIC4 deleted in RPE
This study is looking at how a missing protein in certain eye cells might affect vision and contribute to age-related macular degeneration (AMD) in older adults, with the hope of finding new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10877675 on NIH RePORTER |
What this research studies
This research focuses on understanding dry age-related macular degeneration (AMD), a leading cause of blindness in older adults, by using a novel mouse model that lacks a specific protein called CLIC4 in retinal pigment epithelial cells. The researchers aim to explore how the absence of CLIC4 affects lipid metabolism and contributes to AMD-like symptoms, such as impaired vision and cellular damage. By employing advanced techniques, they will analyze the role of lipids in maintaining the health of retinal cells and how their dysregulation leads to disease progression. This work could provide insights into the mechanisms of AMD and potentially identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing vision problems related to age-related macular degeneration.
Not a fit: Patients with other forms of vision impairment unrelated to age-related macular degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for dry AMD, improving vision and quality of life for affected patients.
How similar studies have performed: Previous research has shown promise in using animal models to study AMD, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Sung, Ching-Hwa — Weill Medical Coll of Cornell Univ
- Study coordinator: Sung, Ching-Hwa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.