Investigating a new model of Alzheimer's Disease using monkeys
Official title: Microscopy characterization of a novel tau model of Alzheimer's Disease in monkeys
Funded at University of California at Davis · NIH-11055123 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects the brain by using specially modified monkeys to learn more about a key problem in the disease, which could help us find better treatments for people with Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $109,595 |
| NIH project number | 1K25AG086663-01A1 |
| Project ID | NIH-11055123 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's Disease or those showing early signs of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's Disease or those who do not exhibit tau pathology may not benefit from this research.
What this research studies
This research focuses on understanding Alzheimer's Disease (AD) by using a monkey model to study tau pathology, which is a key feature of the disease. Researchers will perform detailed microscopic analyses on the brains of rhesus macaques that have been genetically modified to express tau mutations associated with dementia. By observing the progression of tau-related cognitive decline and neuroinflammation over time, the study aims to provide insights that could lead to more effective treatments for AD. The findings from this research could help bridge the gap between animal models and human therapies.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for Alzheimer's Disease, potentially improving the quality of life for patients.
How similar studies have gone: Previous research using animal models has shown promise, but this specific approach using monkeys is relatively novel and untested.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Griggs, Devon — University of California at Davis
- Study coordinator: Griggs, Devon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.