Investigating a new model for HIV persistence in the brain using gene editing techniques
Novel macrophage-tropic transmitted/founder SHIV model of CNS persistence to evaluate CRISPR/Cas9 gene editing
This study is looking at how HIV hides in the brain and testing a new way to use gene editing to help get rid of the virus, which could lead to better treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11078281 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV persists in the brain and aims to develop effective strategies to eliminate the virus. By using a novel animal model that mimics human HIV infection, researchers will explore the characteristics of the virus in the central nervous system (CNS) and test the effectiveness of CRISPR/Cas9 gene editing delivered via adeno-associated viruses (AAV). This approach allows for precise targeting of the virus, potentially leading to breakthroughs in HIV treatment. The study will provide insights into the interactions between the virus and the immune system within the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may benefit from innovative treatment strategies targeting viral persistence.
Not a fit: Patients who are not living with HIV or those who have already achieved viral suppression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eradicate HIV from the brain, improving outcomes for patients living with HIV.
How similar studies have performed: Other research has shown promise in using gene editing techniques for HIV treatment, but this specific approach using a novel animal model is relatively untested.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Bar, Katharine June — University of Pennsylvania
- Study coordinator: Bar, Katharine June
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.