Investigating a new method to monitor dopamine receptors in schizophrenia treatment
Official title: Imaging the Functional State of the D2high Receptor in drug induced dopamine supersensitivity in schizophrenia
Funded at Mclean Hospital · NIH-11045785 · Data updated 2026-11-12
This study is looking at a new way to track certain brain receptors in people with schizophrenia who might be affected by their medication, using a special compound and advanced imaging techniques to make sure it's safe and effective before trying it in humans, with the hope of improving how we manage schizophrenia symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project start | March 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $513,604 |
| NIH project number | 5R01MH134074-02 |
| Project ID | NIH-11045785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with schizophrenia who are currently receiving antipsychotic treatment.
✕Less likely to help
Patients who do not have a diagnosis of schizophrenia or are not on antipsychotic medications may not benefit from this research.
What this research studies
This research focuses on understanding how to effectively monitor dopamine D2high receptors in patients with schizophrenia who may experience dopamine supersensitivity due to antipsychotic medications. By using a specially developed D2high receptor agonist, MCL-524, and advanced imaging techniques like positron emission tomography (PET), the study aims to ensure the safety and effectiveness of this approach before it is tested in humans. The research involves preclinical experiments in animal models to evaluate the binding properties and safety of the compound, which could lead to better management of schizophrenia symptoms.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for schizophrenia, minimizing the risk of worsening symptoms due to medication.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques to monitor receptor activity, suggesting that this approach could be effective.
Where this research is happening
-
Mclean Hospital
Belmont, United States Active
Researchers
- Principal investigator: Subburaju, Sivan — Mclean Hospital
- Study coordinator: Subburaju, Sivan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.