Investigating a new method to control HIV without ongoing treatment
Evaluation of didehydro-Cortistatin A as a block-and-lock agent for a functional HIV cure in a macaque model
This study is looking at a new way to help people with HIV by using a special compound that could keep the virus from waking up, even if they stop taking their usual medications, which could mean a more permanent solution for managing the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10684308 on NIH RePORTER |
What this research studies
This research explores a novel approach to achieve a functional cure for HIV by using a compound called didehydro-Cortistatin A. The goal is to silence the virus in infected cells, preventing it from becoming active again even after stopping antiretroviral therapy. By focusing on the mechanisms that allow HIV to persist in the body, the study aims to provide a long-term solution for individuals living with HIV. Patients may benefit from this research if it leads to a method that allows them to maintain viral control without continuous medication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have achieved viral suppression.
Not a fit: Patients who are not living with HIV or those who have not responded to antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a functional cure for HIV, allowing patients to live without the need for ongoing antiretroviral therapy.
How similar studies have performed: While the block-and-lock approach is a novel strategy, similar research has shown promise in targeting latent HIV reservoirs, indicating potential for success.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Valente, Susana T — University of Florida
- Study coordinator: Valente, Susana T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.