Investigating a new imaging method for Alzheimer's disease using a COX-2 PET ligand
Characterization of an 18F COX-2 PET ligand for in vivo brain imaging
['FUNDING_R01'] · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · NIH-10349436
This study is working on a new imaging tool that can help see levels of a brain protein linked to inflammation in Alzheimer's disease, which could lead to better ways to track the disease and improve treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10349436 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new positron emission tomography (PET) ligand that can visualize COX-2 levels in the brain, which are linked to neuroinflammation in Alzheimer's disease (AD). By using a highly potent [18F]-labeled COX-2 inhibitor, the study aims to create a non-invasive imaging tool that can track COX-2 induction over time, helping to stage the disease and evaluate the effectiveness of COX-2 inhibition therapies. Patients may benefit from improved monitoring of their condition and better-targeted treatments as a result of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring and treatment strategies for Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using PET imaging for neuroinflammation, but this specific approach with COX-2 ligands is novel.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZANDERIGO, FRANCESCA — NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- Study coordinator: ZANDERIGO, FRANCESCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia