Investigating a new imaging method for Alzheimer's disease
Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's disease
This study is exploring a new way to take pictures of the brain to see how tiny structures called microtubules are affected in Alzheimer's disease, which could help improve how we diagnose and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10792864 on NIH RePORTER |
What this research studies
This research focuses on developing a noninvasive imaging technique to quantify microtubules in the brain, which are affected in Alzheimer's disease. Using advanced Positron Emission Tomography (PET) probes, the study aims to measure the integrity of microtubules and their relationship with amyloid beta pathology in animal models. By understanding these interactions, the research seeks to provide insights into the progression of Alzheimer's and the potential protective benefits of microtubule stabilizing agents. Patients may benefit from improved diagnostic methods and treatment strategies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment options for Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using imaging techniques to study neurodegenerative diseases, suggesting potential success for this novel approach.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Solingapuram Sai, Kiran — Wake Forest University Health Sciences
- Study coordinator: Solingapuram Sai, Kiran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.