Investigating a new gene linked to Kallmann syndrome
Official title: Functional dissection of a novel causative gene for Kallmann syndrome
Funded at George Washington University · NIH-10583057 · Data updated 2026-11-12
This study is looking at how a new gene might help us understand Kallmann syndrome, which causes delayed puberty and loss of smell, so we can better support people living with this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 12, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $161,500 |
| NIH project number | 1R03HD110955-01 |
| Project ID | NIH-10583057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Kallmann syndrome or those experiencing symptoms such as delayed puberty and anosmia.
✕Less likely to help
Patients without Kallmann syndrome or those whose symptoms are unrelated to genetic factors may not benefit from this research.
What this research studies
This research focuses on Kallmann syndrome, a condition that leads to delayed puberty and loss of smell due to issues with the development of specific neurons. The study aims to explore the role of a newly identified gene, Neuron-Derived Neurotrophic Factor (NDNF), in regulating important signaling pathways related to this condition. By using advanced genetic techniques, researchers will analyze how this gene affects the migration of neurons and olfactory nerves. The findings could enhance understanding of Kallmann syndrome and improve genetic counseling for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for individuals with Kallmann syndrome.
How similar studies have gone: Previous research has successfully identified other genes associated with Kallmann syndrome, suggesting that this approach may yield valuable insights.
Where this research is happening
-
George Washington University
Washington, United States Active
Researchers
- Principal investigator: Zheng, Xiaoyan — George Washington University
- Study coordinator: Zheng, Xiaoyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.