Investigating a new factor that promotes blood vessel growth in the brain
Official title: Validation of Adenylosuccinate as a Novel Endogenous Pro-Angiogenic Factor in the Brain
Funded at University of North Dakota · NIH-11097229 · Data updated 2026-11-12
This study is looking at how a new substance called adenylosuccinate helps grow blood vessels in the brain, which could be really helpful for people recovering from brain injuries or dealing with low energy situations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Dakota NIH-funded |
| Lab location | 1 site (Grand Forks, United States) |
| Project start | May 15, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $468,207 |
| NIH project number | 5R01NS119279-05 |
| Project ID | NIH-11097229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced brain injuries or are dealing with age-related cognitive decline.
✕Less likely to help
Patients with conditions unrelated to brain angiogenesis or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding how a novel factor called adenylosuccinate (AdSucc) promotes the growth of blood vessels in the brain, which is crucial for recovery from brain injuries and adapting to low energy conditions. The study employs advanced techniques, including 2-photon microscopy, to observe the effects of AdSucc on brain cells in both laboratory settings and living organisms. By exploring the cellular signaling pathways activated by AdSucc, the research aims to uncover new therapeutic strategies for conditions like neurodegeneration and ischemia.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery from brain injuries and improve brain health in aging individuals.
How similar studies have gone: Other research has shown promising results in understanding angiogenesis, but the specific role of adenylosuccinate as a pro-angiogenic factor is a novel area of investigation.
Where this research is happening
-
University of North Dakota
Grand Forks, United States Active
Researchers
- Principal investigator: Golovko, Mikhail Y — University of North Dakota
- Study coordinator: Golovko, Mikhail Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.