Investigating a new factor that promotes blood vessel growth in the brain
Validation of Adenylosuccinate as a Novel Endogenous Pro-Angiogenic Factor in the Brain
['FUNDING_R01'] · UNIVERSITY OF NORTH DAKOTA · NIH-11097229
This study is looking at how a new substance called adenylosuccinate helps grow blood vessels in the brain, which could be really helpful for people recovering from brain injuries or dealing with low energy situations.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NORTH DAKOTA (nih funded) |
| Locations | 1 site (GRAND FORKS, UNITED STATES) |
| Trial ID | NIH-11097229 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a novel factor called adenylosuccinate (AdSucc) promotes the growth of blood vessels in the brain, which is crucial for recovery from brain injuries and adapting to low energy conditions. The study employs advanced techniques, including 2-photon microscopy, to observe the effects of AdSucc on brain cells in both laboratory settings and living organisms. By exploring the cellular signaling pathways activated by AdSucc, the research aims to uncover new therapeutic strategies for conditions like neurodegeneration and ischemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced brain injuries or are dealing with age-related cognitive decline.
Not a fit: Patients with conditions unrelated to brain angiogenesis or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery from brain injuries and improve brain health in aging individuals.
How similar studies have performed: Other research has shown promising results in understanding angiogenesis, but the specific role of adenylosuccinate as a pro-angiogenic factor is a novel area of investigation.
Where this research is happening
GRAND FORKS, UNITED STATES
- UNIVERSITY OF NORTH DAKOTA — GRAND FORKS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLOVKO, MIKHAIL Y — UNIVERSITY OF NORTH DAKOTA
- Study coordinator: GOLOVKO, MIKHAIL Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury