Investigating a new factor that controls cell death in acute kidney injury
Official title: Interferon-Stimulated Gene 15 as a Novel Regulator of Cell Death DuringAcute Kidney Injury
Funded at Washington University · NIH-10995951 · Data updated 2026-11-12
This study is looking at how a protein called ISG15 helps protect kidney cells from damage during acute kidney injury, which could lead to new ways to treat patients who are experiencing this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $35,482 |
| NIH project number | 1F30DK138644-01A1 |
| Project ID | NIH-10995951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute kidney injury, particularly those with ischemia reperfusion injury.
✕Less likely to help
Patients with chronic kidney disease or those not experiencing acute kidney injury may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, interferon-stimulated gene 15 (ISG15), regulates cell death during acute kidney injury (AKI). The study examines the role of ISG15 in preventing damage to kidney cells caused by ischemia reperfusion injury, a common cause of AKI. By using animal models, researchers will explore how manipulating ISG15 can influence kidney cell survival and inflammation, potentially leading to new treatment strategies. Patients with AKI may benefit from insights gained about the mechanisms of cell death and inflammation in their condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating acute kidney injury, improving patient outcomes.
How similar studies have gone: Other research has shown promising results in targeting cell death pathways in kidney injury, suggesting that this approach may lead to significant advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Carpenter, Jessica Marie — Washington University
- Study coordinator: Carpenter, Jessica Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.