Investigating a new factor in phosphate imbalance and heart issues in kidney disease
A Novel Driver of Hyperphosphatemia and Vascular Calcification in CKD
This study is looking at how high phosphate levels can cause heart problems in people with chronic kidney disease, and it's trying to find out how a certain protein in the kidneys affects this process, which could help develop better treatments for heart issues in these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10747948 on NIH RePORTER |
What this research studies
This research focuses on understanding how hyperphosphatemia, a condition characterized by high phosphate levels, contributes to cardiovascular problems in patients with chronic kidney disease (CKD). The team is exploring the role of a specific protein in the kidneys that regulates phosphate absorption and how its dysfunction leads to severe health issues. By using advanced techniques like RNA sequencing and RNA interference, they aim to uncover the mechanisms behind phosphate homeostasis and its impact on heart health. This could lead to new therapeutic strategies for managing cardiovascular complications in CKD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease who are experiencing issues related to high phosphate levels.
Not a fit: Patients without chronic kidney disease or those not experiencing hyperphosphatemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that prevent cardiovascular complications in patients with chronic kidney disease.
How similar studies have performed: Previous research has shown promising results in understanding phosphate regulation in kidney disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Miyazaki, Makoto — University of Colorado Denver
- Study coordinator: Miyazaki, Makoto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.