Investigating a new exercise program for patients with peripheral artery disease
Official title: The effects of a novel, non-ischemic and pain-free exercise intervention in peripheral artery disease
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10904669 · Data updated 2026-11-12
This study is testing a new exercise program called Non-IsChemic Exercise (NICE) for people with peripheral artery disease (PAD) to see if it can help them walk better and feel healthier without causing pain, compared to a regular exercise program that might hurt.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $465,354 |
| NIH project number | 5R01AG071778-02 |
| Project ID | NIH-10904669 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with peripheral artery disease.
✕Less likely to help
Patients who are younger than 65 or do not have peripheral artery disease may not benefit from this research.
What this research studies
This research focuses on a novel exercise intervention called Non-IsChemic Exercise (NICE) designed specifically for patients with peripheral artery disease (PAD). The program aims to improve walking ability, quality of life, and vascular health without causing pain or ischemia, which are common issues with traditional exercise methods. Participants will be randomly assigned to either the NICE program or a standard painful exercise program, allowing researchers to compare the outcomes in terms of ambulation and health-related quality of life. The study will also explore changes in microvascular function and systemic biomarkers associated with these exercise interventions.
Why it matters
Potential benefit: If successful, this research could provide a more effective and pain-free exercise option for patients with peripheral artery disease, enhancing their mobility and overall quality of life.
How similar studies have gone: Previous research has shown promising results with non-painful exercise interventions in similar patient populations, suggesting that this approach may be effective.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Gardner, Andrew W — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Gardner, Andrew W
Related research
Other NIH-funded projects on the same topics.
-
Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.
-
Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life
A program uses game elements on wearable devices to help people 65+ with peripheral artery disease walk more at home and feel better.
-
Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health
This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.
-
Enhancing muscle energy to help leg function in PAD
A study to boost how muscle mitochondria work in people with peripheral artery disease to improve walking and leg function.
-
Low-dose colchicine for people with peripheral artery disease to reduce heart and limb risks
A large international study will test whether a low daily dose of colchicine can lower heart and limb complications for people with peripheral artery disease.
-
Low-dose colchicine for reducing vascular risk in people with PAD
A large international study will test whether a daily low dose of colchicine can lower heart and limb-related risks for people with peripheral artery disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.