Investigating a new drug to enhance brain function in Alzheimer's disease
Early Stage Studies of a Novel Positive Allosteric Modulator of the Alpha1-Adrenergic Receptor to Treat Alzheimer's Disease
This study is testing a new type of medication that could help improve memory and thinking skills for people with Alzheimer's by making the brain's natural chemicals work better, and participants will be checked for any changes in their cognitive abilities during the treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10809626 on NIH RePORTER |
What this research studies
This research focuses on developing a novel type of medication known as a positive allosteric modulator, which aims to improve brain function in patients with Alzheimer's disease. The approach involves targeting specific receptors in the brain to enhance the effects of natural brain chemicals without causing unwanted side effects. By binding to unique sites on these receptors, the drug could potentially improve cognitive functions and slow the progression of Alzheimer's. Patients may be monitored for changes in memory and cognitive abilities during the treatment period.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other types of dementia or cognitive impairments unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option that improves cognitive function and quality of life for patients with Alzheimer's disease.
How similar studies have performed: Other research has shown promise with similar approaches using allosteric modulators, indicating potential for success in this area.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Perez, Dianne M — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Perez, Dianne M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.