Investigating a new driver of triple-negative breast cancer
BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer
This study is looking at a special enzyme called BBOX1 that may help triple-negative breast cancer grow, and by understanding how it works, the researchers hope to find new ways to treat this aggressive cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11049171 on NIH RePORTER |
What this research studies
This research focuses on triple-negative breast cancer (TNBC), a particularly aggressive form of breast cancer. The team is studying a specific enzyme, BBOX1, which is believed to play a crucial role in the growth and metabolism of TNBC cells. By using advanced screening techniques, including both 2-D and 3-D growth assays, the researchers aim to understand how BBOX1 interacts with other cellular components to promote cancer cell proliferation. This could lead to the identification of new therapeutic targets for treating TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple-negative breast cancer.
Not a fit: Patients with other subtypes of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with triple-negative breast cancer.
How similar studies have performed: This research is exploring a novel approach, as the role of BBOX1 in cancer has not been previously established.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Zhang, Qing — Ut Southwestern Medical Center
- Study coordinator: Zhang, Qing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.