Investigating a new coenzyme involved in microbial processes
Nickel-pincer nucleotide enzymes
This study is exploring a new coenzyme called nickel-pincer nucleotide (NPN) that helps certain bacteria, including some that can make us sick, to function better, and by understanding how these bacteria use NPN, we hope to find new ways to fight infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11082384 on NIH RePORTER |
What this research studies
This research focuses on a newly discovered coenzyme called the nickel-pincer nucleotide (NPN), which plays a crucial role in the biochemical processes of certain microorganisms, including those that can cause infections. The project aims to understand how this coenzyme is synthesized and utilized by various bacteria, particularly those associated with the human microbiome. By characterizing the enzymes involved in the NPN biosynthetic pathway, the research seeks to uncover new functions of this coenzyme beyond its known role in lactate racemase. This could lead to insights into microbial metabolism and potential new targets for antimicrobial therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with infections caused by bacteria that utilize the nickel-pincer nucleotide coenzyme.
Not a fit: Patients with infections caused by bacteria that do not utilize the nickel-pincer nucleotide coenzyme may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antimicrobial agents targeting specific bacterial processes.
How similar studies have performed: While the specific investigation of the nickel-pincer nucleotide is novel, similar research approaches have successfully advanced our understanding of microbial coenzymes and their roles in pathogenicity.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Hausinger, Robert P — Michigan State University
- Study coordinator: Hausinger, Robert P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.