Investigating a new chemokine's role in breast cancer spread
Official title: Novel chemokine in the regulation of breast cancer metastasis
Funded at University of Louisville · NIH-11223046 · Data updated 2026-11-12
This study is looking at how a protein called CCL24 affects the growth and spread of aggressive breast cancer, especially in cases that don't respond to estrogen, to find new ways to treat patients better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $407,391 |
| NIH project number | 7R21CA286376-02 |
| Project ID | NIH-11223046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with aggressive estrogen receptor-negative breast cancer.
✕Less likely to help
Patients with non-aggressive breast cancer or those with estrogen receptor-positive breast cancer may not benefit from this research.
What this research studies
This research focuses on understanding how a specific chemokine, CCL24, influences the spread of aggressive breast cancer, particularly in estrogen receptor-negative cases. The team has found that higher levels of CCL24 are linked to worse outcomes for patients, suggesting it plays a critical role in cancer progression. By studying how CCL24 affects cancer cell behavior and the immune response, the researchers aim to identify new therapeutic targets that could help in treating breast cancer more effectively.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms of breast cancer metastasis, improving patient outcomes.
How similar studies have gone: While the specific role of CCL24 in breast cancer is being explored, similar research has shown promise in targeting chemokines for cancer treatment, indicating potential for success.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Karan, Dev — University of Louisville
- Study coordinator: Karan, Dev
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.