Investigating a new cause of congenital heart disease
"SHROOM3 is a Novel Cause of Congenital Heart Disease"
This study is looking at a gene called SHROOM3 to see how it affects heart development and could help us understand and treat congenital heart disease, which is a major cause of heart problems in babies.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10860955 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a gene called SHROOM3 in congenital heart disease (CHD), which is a leading cause of death from birth defects. The researchers are using advanced techniques, including genetic analysis and mouse models, to explore how SHROOM3 affects heart development and its potential links to other birth defects. By studying the genetic interactions and pathways involved, they aim to uncover the mechanisms that lead to CHD and identify new therapeutic targets. This work could provide valuable insights into the prevention and treatment of heart defects in newborns.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital heart disease or those with a family history of heart defects.
Not a fit: Patients with congenital heart disease caused by factors unrelated to genetic mutations in SHROOM3 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and targeted therapies for congenital heart disease.
How similar studies have performed: Other research has shown success in identifying genetic causes of congenital heart disease, suggesting that this approach could yield valuable findings as well.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Durbin, Matthew D. — Indiana University Indianapolis
- Study coordinator: Durbin, Matthew D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.