Investigating a new biomarker for Alzheimer's disease.
Evaluation of Monoamine Oxidase-A as a New Biomarker for Alzheimer's Disease
This study is looking at a brain chemical called MAO-A to see if it can help us understand Alzheimer's disease better, and if you have Alzheimer's, you might get to participate in a safe imaging test to see how this chemical behaves in your brain compared to those without the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10525579 on NIH RePORTER |
What this research studies
This research focuses on evaluating Monoamine Oxidase-A (MAO-A) as a potential biomarker for Alzheimer's disease (AD). The study employs advanced imaging techniques and radiotracers to assess MAO-A levels in the brains of individuals with AD compared to healthy controls. By understanding the role of MAO-A in neurodegeneration, the research aims to provide insights into the disease's progression and potential treatment targets. Patients may undergo noninvasive imaging to help identify changes in MAO-A activity associated with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better-targeted therapies for Alzheimer's disease.
How similar studies have performed: While there have been studies on MAO-A in other conditions, this specific approach in Alzheimer's disease is novel and has not been extensively tested.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Mukherjee, Jogeshwar — University of California-Irvine
- Study coordinator: Mukherjee, Jogeshwar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.