Investigating a new approach to target the MYC protein in cancer
High-Throughput Screen for the Oncoprotein MYC
This study is looking for new ways to help treat cancers linked to the MYC protein by testing a promising compound called RSH470 and finding other similar compounds that can stop MYC from causing problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10881725 on NIH RePORTER |
What this research studies
This research focuses on the MYC protein, a critical regulator involved in cell growth and cancer development. The team has discovered a compound called RSH470 that binds to MYC and shows promise in inhibiting its activity. They are developing a high-throughput screening assay to identify additional MYC inhibitors without the need for complex modifications. This approach aims to find effective treatments for cancers where MYC plays a significant role.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers associated with MYC overexpression, such as breast cancer.
Not a fit: Patients with cancers not driven by MYC or those with early-stage cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies targeting MYC, potentially improving outcomes for patients with various cancers.
How similar studies have performed: Previous research has shown promise in targeting MYC, but this specific approach using RSH470 is novel and has not been extensively tested.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Janda, Kim — Scripps Research Institute, the
- Study coordinator: Janda, Kim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.