Investigating a new approach to prevent nerve damage in Alzheimer's disease
Official title: Exploring annexin A6 for the prevention of dystrophic neurites and tau seeding and spreading in Alzheimer's disease
Funded at Northwestern University at Chicago · NIH-11003330 · Data updated 2026-11-12
This study is looking at how a protein called annexin A6 might protect nerve cells from damage caused by amyloid plaques in Alzheimer's disease, with the hope of finding new ways to help improve memory and reduce side effects from current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $675,876 |
| NIH project number | 5R01AG081649-02 |
| Project ID | NIH-11003330 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it due to genetic or environmental factors.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding how a protein called annexin A6 can help prevent damage to nerve cells caused by amyloid plaques in Alzheimer's disease. The study aims to explore the mechanisms by which amyloid beta peptides lead to tau protein abnormalities, which are linked to memory loss and dementia. By targeting these processes, the research seeks to develop new therapeutic strategies that could improve patient outcomes and reduce side effects associated with current Alzheimer's treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Alzheimer's disease that minimize side effects and improve cognitive function.
How similar studies have gone: Other research has shown promise in targeting amyloid and tau pathways in Alzheimer's, indicating that this approach could be a valuable addition to existing therapies.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Vassar, Robert J — Northwestern University at Chicago
- Study coordinator: Vassar, Robert J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.