Investigating a new antibody treatment for HIV
High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 3
This study is testing a new treatment called SAR441236, which is a special antibody designed to help people living with HIV by targeting the virus in multiple ways, and it's for both those who have active HIV and those who have it under control to see if it can help clear the virus and boost their immune system.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11080777 on NIH RePORTER |
What this research studies
This research focuses on a novel tri-specific broadly neutralizing antibody (bnAb) called SAR441236, which targets multiple sites on the HIV virus to enhance its effectiveness. The study aims to evaluate how this antibody can impact the HIV reservoir in patients, potentially leading to better control of the virus. Participants will receive this treatment to see if it can clear residual HIV and improve immune function, thereby enhancing overall treatment outcomes. The research involves both viremic and aviremic individuals living with HIV, assessing the antibody's effects on their health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, both those with active viral loads and those who are virally suppressed.
Not a fit: Patients who are not living with HIV or those who have not responded to previous HIV treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV treatments that improve patient adherence and outcomes.
How similar studies have performed: Other research has shown promise with similar antibody approaches, indicating potential for significant advancements in HIV treatment.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Tsibris, Athe M. — Brigham and Women's Hospital
- Study coordinator: Tsibris, Athe M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.